8 research outputs found
Relaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice
- Author
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- Field of study
Landsat 9 Thermal Infrared Sensor 2 Architecture and Design
- Author
- Alexander David
- Ballou Kevin
- Barclay Richard
- Coulter Phillip
- Djam Melody
- Edick Michael
- Efremova Boryana
- Finneran Paul
- Florez Jose
- Graham Steven
- Hair Jason H.
- Harbert Kenneth
- Hewitt Dennis
- Hickey Michael
- Hicks Samantha
- Hoge William
- Jhabvala Murzban
- Lilly Carol
- Lunsford Allen
- Mann Laurie
- Masters Candace
- McCorkel Joel T.
- Montanaro Matthew
- Muench Theodore
- Otero Veronica
- Parong Fil
- Pearlman Aaron
- Penn Jonathan
- Reuter Dennis C.
- Simon Amy A.
- Tonn Synthia L.
- Vigneau Danielle
- Wenny Brian
- Publication venue
- Publication date
- Field of study
The Thermal Infrared Sensor 2 (TIRS-2) will fly aboard the Landsat 9 spacecraft and leverages the Thermal Infrared Sensor (TIRS) design currently flying on Landsat 8. TIRS-2 will provide similar science data as TIRS, but is not a buildto-print rebuild due to changes in requirements and improvements in absolute accuracy. The heritage TIRS design has been modified to reduce the influence of stray light and to add redundancy for higher reliability over a longer mission life. The TIRS-2 development context differs from the TIRS scenario, adding to the changes. The TIRS-2 team has also learned some lessons along the way
Landsat 9 TIRS-2 Architecture and Design
- Author
- Alexander David
- Ballou Kevin
- Barclay Richard
- Coulter Phillip
- Djam Melody
- Edick Michael
- Efremova Boryana
- Finneran Paul
- Florez Jose
- Graham Steven
- Hair Jason H.
- Harbert Kenneth
- Hewitt Dennis
- Hickey Michael
- Hicks Samantha
- Hoge William
- Jhabvala Murzy
- Lilly Carol
- Lunsford Allen
- Mann Laurie
- Masters Candace
- McCorkel Joel
- Montanaro Matthew
- Muench Theodore
- Otero Veronica
- Parong Fil
- Pearlman Aaron
- Penn Jonathan
- Reuter Dennis C.
- Simon Amy A.
- Tonn Synthia L.
- Vigneau Danielle
- Wenny Brian
- Publication venue
- Publication date
- Field of study
No abstract availabl
Landsat 9 TIRS-2 Architecture and Design
- Author
- Alexander David S.
- Ballou Kevin
- Barclay Richard B.
- Coulter Phillip
- Djam Melody
- Edick Michael G.
- Efremova Boryana
- Finneran Paul A.
- Florez Jose M.
- Graham Steven M.
- Hair Jason H.
- Harbert Kenneth J.
- Hewitt Dennis R.
- Hickey Michael R.
- Hicks Samantha L.
- Hoge William J.
- Jhabvala Murzban D.
- Lilly Carol W.
- Lunsford Allen W.
- Mann Laurie M.
- Masters Candace M.
- Mccorkel Joel T.
- Montanaro Matthew
- Muench Theodore
- Otero Veronica
- Parong Fil
- Pearlman Aaron
- Penn Jonathan
- Reuter Dennis C.
- Simon Amy A.
- Tonn Synthia L.
- Vigneau Danielle
- Wenny Brian
- Publication venue
- Publication date
- Field of study
TIRS-2 will fly on the LandSat 9. Like TIRS on Landsat 8, TIRS-2 will produce radiometrically calibrated, geo-located thermal image data. USGS is responsible for operational code. TIRS-2 image data will have the same performance characteristics as that of TIRS on Landsat 8 except better in some cases
Modulation of Radiation-Induced Genetic Damage by HCMV in Peripheral Blood Lymphocytes from a Brain Tumor Case-Control Study
- Author
- AbuBakar
- Albrecht
- Albrecht
- Boldogh
- Boldogh
- Bonassi
- Bondy
- Bondy
- Carol J. Etzel
- Claudia M. Monroy
- Cobbs
- Deng
- Dion
- Edick
- El-Zein
- El-Zein
- Elizabeth A. Rourke
- Evans
- Fenech
- Fruehauf
- Gaspar
- Hodges
- Marekova
- Melissa L. Bondy
- Michael E. Scheurer
- Michaelis
- Mirtha S. Lopez
- Mozdarani
- Murgia
- Ohagen
- Randa A. El-Zein
- Relling
- Schwartzbaum
- Shanley
- Skaletskaya
- Solomon
- Thomas Albrecht
- Wang
- Wrensch
- Wu
- Yount
- Zhu
- Publication venue
- 'MDPI AG'
- Publication date
- Field of study
Explaining citizens' attitudes toward pornography: Differential effects of predictors across levels of geographic proximity to outlet sources
- Author
- Abelson H.
- Amoah J.
- Beckett J.
- Berschback D.
- Cottle C.
- Cowan G.
- Cowan G.
- Crank J.
- Edick D.
- Etzioni A.
- Fisher W.
- Forna A.
- Goldstein M.
- Heiman M.
- Hixson R.
- Kraft M.
- Krause J.
- Lavrakas P.
- Linz D.
- Major M.
- Massey M.
- Mayall A.
- Michael B. Blankenship
- Nakell B.
- Peele E.
- Reiss I.
- Reiss I.
- Ritts V.
- Russell D.
- Scott J.
- Stephen G. Tibbetts
- Stewart J.
- Strossen N.
- Wallace J.
- Wexler M.
- Willis E.
- Winick C.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
- Azar M
- Azbel L
- Azizuyo B
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- Back D
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated